PERK/EIF2AK3 Antibody 8 Publications

Rabbit Polyclonal| Catalog number: 20582-1-AP

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Con: 69 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
K-562 cells, HEK-293 cells, K-562 cells, MCF-7 cells, mouse pancreas tissue

Positive IHC detected in:
human pancreas tissue, human pancreas tissue, human placenta tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
eukaryotic translation initiation factor 2-alpha kinase 3

Calculated molecular weight:
125 kDa

Observed molecular weight:
140 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
EIF2AK3

Synonyms
DKFZp781H1925, EIF2AK3, HRI, HsPEK, Pancreatic eIF2 alpha kinase, PEK, PERK, WRS
Background

PERK, also named as EIF2AK3 and PEK, belongs to the protein kinase superfamily, Ser/Thr protein kinase family and GCN2 subfamily. PERK phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. PERK serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1. It catalyzes the reaction: ATP + a protein = ADP + a phosphoprotein. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS). The antibody is specific to PERK.


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