PKM Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 10078-2-AP

Featured Product KD/KO validated

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Con: 21 μg/150 μl

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Species specificity:
human, mouse, pig

Positive WB detected in:
multi-cells/tissue, HEK-293 cells

Positive IHC detected in:
human colon cancer tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
PKM2 pyruvate kinase, muscle

Calculated molecular weight:
58 kDa

Observed molecular weight:
58 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PKM2

Synonyms
CTHBP, OIP 3, OIP3, Opa interacting protein 3, p58, PK2, PK3, PKM, PKM1, PKM2, PKM2 pyruvate kinase, muscle, Pyruvate kinase 2/3, Pyruvate kinase isozymes M1/M2, Pyruvate kinase muscle isozyme, TCB, THBP1, Tumor M2 PK
Background

PKM, also named as OIP3, PK2, PK3, PK-M1/2, p58, THBP1, CTHBP and Tumor M2-PK, belongs to the pyruvate kinase family. It is glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. It stimulates POU5F1-mediated transcriptional activation. PKM plays a general role in caspase independent cell death of tumor cells. The activity of the M2 isoform (but not the M1 isoform) can be inhibited by tyrosine kinase signalling in tumourcells.The primary pyruvate kinase isoform before tumour development is PK-M1; however, the primary isoform from four independent tumours is PK-M2.(PMID:18337823). PKM, Pyruvate kinase isozymes M1/M2, has 2 isoforms . This antibody can recognize both PK-M1 and PK-M2.


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