PKC alpha Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 21991-1-AP

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Freight/Packing

Con: 54 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
Jurkat cells, HEK-293 cells, NIH/3T3 cells

Positive IP detected in:
NIH/3T3 cells

Positive IHC detected in:
human thyroid cancer tissue

Positive IF detected in:
HeLa cells, NIH/3T3 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
protein kinase C, alpha

Calculated molecular weight:
77 kDa

Observed molecular weight:
77 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PRKCA

Synonyms
AAG6, PKC A, PKC alpha, PKCA, PRKACA, PRKCA, Protein kinase C alpha type, protein kinase C, alpha
Background

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. PRKCA is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.


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