PTPRS Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 13008-1-AP

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Con: 90 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HeLa cells, HeLa cells, mouse brain tissue

Positive IP detected in:
mouse brain tissue

Positive IHC detected in:
human ovary tumor tissue

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
protein tyrosine phosphatase, receptor type, S

Calculated molecular weight:
128aa,14 kDa;1948aa,217 kDa

Observed molecular weight:
75-100 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PTPRS

Synonyms
PTPRS, PTPSIGMA, R PTP S, R PTP sigma, rPTPσ
Background

Type IIa receptor protein tyrosine phosphatases (rPTPσ) are cell surface receptors important for nervous system development, function, and repair.The expression ofrPTPσ has previously been reported in b-cells and other target organs for insulin although the probes chosen did not permit to distinguish between the splice variants.Proteolytic processing near the transmembrane domain generates an extracellular N-terminal E-domain of 130 kDa and a C-terminal P-domain of approximately 85 kDa of rPTPσ,and the short splice variants rPTPσ 3 and 4contain an E-domain of 95 kDa(PMID:16552719). rPTPσ expression was observed in tissue lysates of the adult mouse sensory-motor cortex and thoracic spinal cord (T8-T10) as a 75–80kDa immunoreactive band(PMID:19780196).


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