S100A4 Antibody 7 Publications

Rabbit Polyclonal| Catalog number: 16105-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 34 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
HeLa cells, NIH/3T3 cells

Positive IHC detected in:
human breast cancer tissue, human colon cancer tissue, human pancreas cancer tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
S100 calcium binding protein A4

Calculated molecular weight:
101aa,12 kDa

Observed molecular weight:
10-12 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
S100A4

Synonyms
18A2, 42A, Calvasculin, CAPL, Fibroblast Specific Protein, FSP1, Metastasin, MTS1, P9KA, PEL98, Protein Mts1, Protein S100 A4, S100A4
Background

S100A4 is a member of the S100 family of calcium-binding proteins. The S100 family members have been involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100A4 is known to localize to and function in the nucleus, cytoplasm of cells, and the extracellular space. S100A4 has also been shown to be associated with tumor growth, motility, invasion, metastasis, angiogenesis, apoptosis, and chemoresistance. It is a fibroblast-specific protein associated with mesenchymal cell morphology and motility, is expressed during epithelial-mesenchymal transformations (EMT) in vivo (PMID: 9362334). It is a specific prognostic marker for renal survival in patients with IgAN (PMID: 16105038). It is also an improved marker for lung fibroblasts that could be useful for investigating the pathogenesis of pulmonary fibrosis(PMID: 15618458). Overexpression of S100A4 is correlated with a worse prognosis inpatients with various types of cancer.


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