SORCS1 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 18839-1-AP

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Freight/Packing

Con: 35 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
Y79 cells, HEK-293 cells, mouse brain tissue, Y79 cells

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:1000

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
sortilin-related VPS10 domain containing receptor 1

Calculated molecular weight:
1168aa,130 kDa

Observed molecular weight:
130 kDa, 60-80 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
SORCS1

Synonyms
hSorCS, SORCS1
Background

SorCS1 is a 130 kDa type I transmembrane protein, belonging to Vps10p-domain (Vps10p-D) receptor family that comprises an N-terminal Vps10p-D, a leucine-rich domain, a single transmembrane domain, and a short cytoplasmic domain. SorCS1 is synthesized as a proprotein, which is converted to the mature receptor in late Golgi compartments by cleavage of the N-terminal propeptide. Alternative splicing of human SorCS1 results in four isoforms with different cytoplasmic domains and differential expression in tissues. This antibody was generated against the C-terminal region of human SorCS1 and recognizes various forms of SorCS1. Multiple bands around 100-130 kDa as well as 60-80 kDa have been detected in Y79 cells by western blot assay.


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