|Positive WB detected in||PC-12 cells, SH-SY5Y cells|
|Positive IF detected in||SH-SY5Y cells|
|Western Blot (WB)||WB : 1:3000-1:20000|
|Immunofluorescence (IF)||IF : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
66334-1-Ig targets TH in WB, IHC, IF, ELISA applications and shows reactivity with human samples.
|Host / Isotype||Mouse / IgG1|
|Immunogen||TH fusion protein Ag23075|
|Full Name||tyrosine hydroxylase|
|Calculated molecular weight||528 aa, 59 kDa|
|Observed molecular weight||55 kDa|
|GenBank accession number||BC104967|
|Gene ID (NCBI)||7054|
|Purification Method||Protein G purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
TH(Tyrosine 3-monooxygenase) converts L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA), the essential and rate-limiting step to formation of DA and other catecholamines. TH plays an important role in the physiology of adrenergic neurons and can be used as a marker for DA and noradrenergic neurons.
CNS Neurosci Ther
Transplantation of Nurr1-overexpressing neural stem cells and microglia for treating parkinsonian rats.
Exp Ther Med
Wnt1 silencing enhances neurotoxicity induced by paraquat and maneb in SH-SY5Y cells.
Inhibition of HDAC6 increases acetylation of peroxiredoxin1/2 and ameliorates 6-OHDA induced dopaminergic injury.
Biochem Biophys Res Commun
Mitochondrial dysfunction in dopaminergic neurons differentiated from exfoliated deciduous tooth-derived pulp stem cells of a child with Rett syndrome.
Eur J Pharmacol
Asparagine endopeptidase inhibitor protects against fenpropathrin-induced neurodegeneration via suppressing α-synuclein aggregation and neuroinflammation.