TRBP Antibody 4 Publications

Rabbit Polyclonal| Catalog number: 15753-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 63 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HepG2 cells, HepG2 cells, mouse liver tissue, mouse spleen tissue

Positive IP detected in:
mouse liver tissue

Positive IHC detected in:
human brain tissue, human brain tissue, human kidney tissue, human ovary tissue, human placenta tissue, human spleen tissue, human testis tissue

Positive IF detected in:
Hela cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:3000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
TAR (HIV-1) RNA binding protein 2

Calculated molecular weight:
39 kDa

Observed molecular weight:
43-46 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
TARBP2

Synonyms
LOQS, TAR RNA binding protein 2, TARBP2, TRBP, TRBP1, TRBP2
Background

TARBP2 is a component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC). Within the complex, TARBP2 and DICER1 are required to process precursor miRNAs (pre-miRNA) to mature miRNA and then load them onto EIF2C2/AGO2. It may has a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Otherwise, it binds to the HIV-1 TAR RNA that is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. TARBP2 is a component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC). Within the complex, TARBP2 and DICER1 are required to process precursor miRNAs (pre-miRNA) to mature miRNA and then load them onto EIF2C2/AGO2. It may has a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Otherwise, it binds to the HIV-1 TAR RNA that is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. The endogenous TRBP that was present in HEK293 cells, with apparent molecular masses of 43–46 kDa, are expressed in human cells. (PMID: 16142218)


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