VCP Antibody 0 Publications

Mouse Monoclonal| Catalog number: 60316-1-Ig |CloneNo.: 2A4B10

Featured Product KD/KO validated

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Con: 100 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
RAW 264.7 cells, HeLa cells, SH-SY5Y cells

Positive IHC detected in:
human gliomas tissue

Positive IF detected in:
RAW 264.7 cells, SH-SY5Y cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
valosin-containing protein

Calculated molecular weight:
71 kDa

Observed molecular weight:
89 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
VCP

Synonyms
15S Mg(2+) ATPase p97 subunit, IBMPFD, p97, TER ATPase, TERA, valosin containing protein, VCP
Background

VCP(Valosin-containing protein) belongs to the AAA ATPase family.VCP was first identified as a result of attempts to clone a putative peptide hormone called valosin. It was found that the cloned cDNA encoded a ubiquitously expressed 90 kDa cytosolic protein, termed VCP, which showed none of the characteristics of a peptide hormone precursor(PMID:1382975).Defects in VCP are the cause of inclusion body myopathy with early-onset Paget disease and frontotemporal dementia (IBMPFD) and amyotrophic lateral sclerosis type 14 with or without frontotemporal dementia (ALS14)


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