ubiquitin Antibody 1 Publications

Mouse Monoclonal| Catalog number: 60310-1-Ig |CloneNo.: 1D7B2

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Con: 97 μg/150 μl

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Species specificity:
human

Positive WB detected in:
HeLa cells

Positive IHC detected in:
human ovary tumor tissue, human breast cancer tissue, human ovary tumor tissue, human pancreas tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
ubiquitin B

Calculated molecular weight:
26 kDa

Observed molecular weight:
25 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
UBB

Synonyms
FLJ25987, Polyubiquitin B, UBB, ubiquitin, ubiquitin B
Background

Ubiquitin B (UBB) is a member of ubiquitin family, one of the most conserved proteins known. Ubiquitin B is required for ATP-dependent, non-lysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin B is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression.When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome. Interestingly ubiquitin also becomes covalently bonded to many types of pathological inclusions which appear to be resistant to normal degradation.


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