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CIRBP Monoklonaler Antikörper

CIRBP Monoklonal Antikörper für ELISA

Wirt / Isotyp

Maus / IgM

Getestete Reaktivität

human, Maus

Anwendung

IHC,ELISA

Konjugation

Unkonjugiert

CloneNo.

4D12H7

Kat-Nr. : 60025-2-Ig

Synonyme

Galerie der Validierungsdaten

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  • Western Blot (WB) analysis of HEK-293 cells using CIRBP Monoclonal antibody (60025-2-Ig)

    WB analysis of HEK-293 using 60025-2-Ig

    HEK-293 cells were subjected to SDS PAGE followed by western blot with 60025-2-Ig (CIRBP antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

  • Immunohistochemistry (IHC) staining of human tonsillitis tissue using CIRBP Monoclonal antibody (60025-2-Ig)

    IHC staining of human tonsillitis using 60025-2-Ig

    Immunohistochemical analysis of paraffin-embedded human tonsillitis slide using 60025-2-Ig (CIRBP Antibody) at dilution of 1:50.

Geprüfte Anwendungen

Empfohlene Verdünnung

AnwendungVerdünnung
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

IHCSee 1 publications below

Produktinformation

60025-2-Ig bindet in IHC,ELISA CIRBP und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
In Publikationen genannte Reaktivitäthuman
Wirt / Isotyp Maus / IgM
Klonalität Monoklonal
Typ Antikörper
Immunogen CIRBP fusion protein Ag0280
Vollständiger Name cold inducible RNA binding protein
Berechnetes Molekulargewicht 172 aa, 19 kDa
Beobachtetes Molekulargewicht 19 kDa
GenBank-ZugangsnummerBC000403
Gene symbol CIRBP
Gene ID (NCBI) 1153
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Caprylsäure/Ammoniumsulfat-Präzipitation
Lagerungspuffer PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
LagerungsbedingungenBei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

CIRBP, also named as A18HNRNP and CIRP, is a cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. CIRBP is also involved in cap-independent translation upon moderate cold-shock. It acts as a translational activator. CIRBP is a suppressive rather stimulatory effect on proliferation. It acts as a translational repressor. CIRBP is an immortalized gene in murine primary cells. CIRBP promotes assembly of stress granules (SGs), when overexpressed. It is a potential proto-oncogenic proteins upon overexpression.(PMID:19900510) Suppression of CIRBP increased the apoptotic cell population of neural stem cells at moderate low temperature. (PMID:20735994) This antibody can bind the close sequences genes. This antibody is a mouse monoclonal antibody raised against full length CIRBP of human origin.

Publikationen

SpeciesApplicationTitle
humanIHC

Ann Dermatol

Expression of Cold-Inducible RNA-Binding Protein in Normal Skin, Actinic Keratosis and Squamous Cell Carcinoma.

Authors - Bo Mi Park
View Article