GEFT-Specific Polyklonaler Antikörper

GEFT-Specific Polyklonal Antikörper für ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IHC, IF, ELISA

Konjugation

Unkonjugiert

Publikationen(14)

Rezensionen (1)

Kat-Nr. : 14839-1-AP

Synonyme

GEFT, ARHGEF25, RhoA/RAC/CDC42 exchange factor, Rho guanine nucleotide exchange factor 25, p63RhoGEF

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Geprüfte Anwendungen

Veröffentlichte Anwendungen

• KD/KO: See 1 publications below
• WB: See 13 publications below
• IHC: See 3 publications below
• IF: See 3 publications below

Produktinformation

14839-1-AP bindet in WB, IHC, IF, ELISA GEFT-Specific und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• In Publikationen genannte Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: Peptid
• Vollständiger Name: RhoA/RAC/CDC42 exchange factor
• Berechnetes Molekulargewicht: 64 kDa
• Beobachtetes Molekulargewicht: 64 kDa
• GenBank-Zugangsnummer: NM_182947
• Gene symbol: GEFT
• Gene ID (NCBI): 115557
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

GEFT, also named as p63RhoGEF, may play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. GETF links specifically G alpha q/11-coupled receptors to RHOA activation. GEFT may be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. It is involved in skeletal myogenesis. GEFT is expressed as three isoforms (64, 53 and 68 kDa).

Publikationen

Species	Application	Title
mouse	WB	Genes Dev; TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway.; Authors - Kant Shashi S
human	WB	Circ Res; p63RhoGEF couples Gα(q/11)-mediated signaling to Ca2+ sensitization of vascular smooth muscle contractility.; Authors - Momotani Ko K
mouse	WB	Sci Signal; RSK2 contributes to myogenic vasoconstriction of resistance arteries by activating smooth muscle myosin and the Na+/H+ exchanger.; Authors - Mykhaylo V Artamonov
rat	WB,IHC	FASEB J; p63RhoGEF--a key mediator of angiotensin II-dependent signaling and processes in vascular smooth muscle cells.; Authors - Wuertz Christina M CM
mouse	WB,IHC,IF	Mol Cell Biol; Modulation of muscle regeneration, myogenesis, and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT.; Authors - Bryan Brad A BA
human	WB	J Hypertens; Increased level of p63RhoGEF and RhoA/Rho kinase activity in hypertensive patients.; Authors - Lorenzo A Calò

Rezensionen

The reviews below have been submitted by verified Proteintech customers who received an incentive for providing their feedback.

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FH

Joelle (Verified Customer) (09-10-2019)

Overnight at 4 degrees

• Applications: Western Blot,
• Primary Antibody Dilution: 1/1000
• Cell Tissue Type: HHL16

GEFT-Specific Antibody Western Blot, validation (1/1000 dilution) in HHL16 (Cat no:14839-1-AP)