IFN-gamma Monoklonaler Antikörper

IFN-gamma Monoklonal Antikörper für FC (Intra)

Wirt / Isotyp

Ratte / IgG1, kappa

Getestete Reaktivität

Maus

Anwendung

FC (Intra)

Konjugation

FITC Plus Fluorescent Dye

Publikationen(1)

CloneNo.

XMG1.2

Kat-Nr. : FITC-65153

Synonyme

IFN gamma, Ifng, IFN-gamma,IFN gamma,IFN γ,IFNγ, IFN γ, IFN g



Geprüfte Anwendungen

Erfolgreiche Detektion in FC (Intra)PMA and ionomycin Stimulate C57BL/6 Th1-polarized splenocytes

Empfohlene Verdünnung

AnwendungVerdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

FITC-65153 bindet in FC (Intra) IFN-gamma und zeigt Reaktivität mit Maus

Getestete Reaktivität Maus
In Publikationen genannte ReaktivitätMaus
Wirt / Isotyp Ratte / IgG1, kappa
Klonalität Monoklonal
Typ Antikörper
Immunogen Purified Recombinant Mouse IFN gamma
Vollständiger Name interferon gamma
Berechnetes Molekulargewicht17 kDa
GenBank-ZugangsnummerBC119063
Gene symbol IFN gamma
Gene ID (NCBI) 15978
Konjugation FITC Plus Fluorescent Dye
Excitation/Emission maxima wavelengths495 nm / 524 nm
Form Liquid
Reinigungsmethode Affinitätsreinigung
Lagerungspuffer PBS with 0.09% sodium azide
LagerungsbedingungenStore at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Hintergrundinformationen

Interferon gamma (IFN γ), is a type II interferon that provides immunity against bacterial, viral and protozoan infections. In its active form, IFN γ is a glycosylated, non-covalently linked homodimer of 29-32 kDa subunits. It is produced by a number of immune cell types including natural killer cells, natural killer T cells, and effector lymphocyte T cells following antigenic and inflammatory triggers. The IFN γ dimer binds to its cognate receptor which has two subunits: IFN-γR1 which is the ligand-binding chain (α chain) and IFN-γR2, the signal-transducing chain (β chain). Binding to the receptor activates the JAK/STAT pathway which in turn activates IFN γ responsive genes. While IFN γ can inhibit viral replication, it also works as an immune-modulator and immune-stimulator by increasing surface expression of class I MHC proteins. (PMID: 19268625; 10688427)

Protokolle

PRODUKTSPEZIFISCHE PROTOKOLLE
FC protocol for FITC Plus IFN-gamma antibody FITC-65153Download protocol
STANDARD-PROTOKOLLE
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Publikationen

SpeciesApplicationTitle
mouseFC (Intra)

Acta Biomater

Injectable microenvironment-responsive hydrogels with redox-activatable supramolecular prodrugs mediate ferroptosis-immunotherapy for postoperative tumor treatment

Authors - Zhuo Cheng