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  • KD/KO Validated

RORA Polyklonaler Antikörper

RORA Polyklonal Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human und mehr (2)

Anwendung

WB, IP, IHC, ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 10616-1-AP

Synonyme

NR1F1, Nuclear receptor ROR alpha, Nuclear receptor RZR alpha, RAR related orphan receptor A, RORA, RZR ALPHA, RZRA



Geprüfte Anwendungen

Erfolgreiche Detektion in WBDU 145-Zellen, HeLa-Zellen, Jurkat-Zellen, K-562-Zellen, L02-Zellen, PC-3-Zellen, SMMC-7721-Zellen

Empfohlene Verdünnung

AnwendungVerdünnung
Western Blot (WB)WB : 1:500-1:2000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

10616-1-AP bindet in WB, IP, IHC, ELISA RORA und zeigt Reaktivität mit human

Getestete Reaktivität human
In Publikationen genannte Reaktivitäthuman, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen RORA fusion protein Ag0944
Vollständiger Name RAR-related orphan receptor A
Berechnetes Molekulargewicht 59 kDa
Beobachtetes Molekulargewicht 65-70 kDa
GenBank-ZugangsnummerBC008831
Gene symbol RORA
Gene ID (NCBI) 6095
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
LagerungsbedingungenBei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

RORA is a steroid hormone receptor and has been implicated in the pathology of circadian rhythms, bone growth, angiogenesis, development of cones, cellular metabolism and a mediator in the immune and lipid metabolism pathways [PMID:21998696]. It binds DNA as a monomer to hormone response elements (HRE) containing a single core motif half-site preceded by a short A-T-rich sequence, which binds to the consensus sequence 5'-[AT][TA]A[AT][CGT]TAGGTCA-3'. Regulates a number of genes involved in lipid metabolism such as apolipoproteins AI, APOA5, CIII, CYP71 and PPAR gamma, in cerebellum and photoreceptor development including PCP2, OPN1SW, OPN1SM and ARR3, in circadian rhythm with BMAL1, and skeletal muscle development with MYOD1 [PMID:11053433,14570920].

Protokolle

Produktspezifische Protokolle
WB protocol for RORA antibody 10616-1-APProtokoll herunterladen
Standard-Protokolle
Klicken Sie hier, um unsere Standardprotokolle anzuzeigen

Publikationen

SpeciesApplicationTitle
mouseWB

Nat Commun

A proteomics landscape of circadian clock in mouse liver.

Authors - Yunzhi Wang
mouseWB

Free Radic Biol Med

Hydrogen peroxide modulates clock gene expression via PRX2-STAT3-REV-ERBα/β pathway.

Authors - Guohua Ji
  • KD Validated
mouseWB

J Cell Physiol

MCPIP1 regulates RORα expression to protect against liver injury induced by lipopolysaccharide via modulation of miR-155.

Authors - Zhenzhen Li
humanWB

Int Immunopharmacol

ILC2s induce adaptive Th2-type immunity in different stages of tuberculosis through the Notch-GATA3 pathway.

Authors - Qifeng Li
ratWB

Front Physiol

PMID: 26696906

Authors - You-Lin Tain
ratWB

Biol Reprod

Maternal melatonin or agomelatine therapy prevents programmed hypertension in male offspring of mother exposed to continuous light.

Authors - You-Lin Tain