Anticorps Monoclonal anti-CIRBP

CIRBP Monoclonal Antibody for ELISA

Hôte / Isotype

Mouse / IgM

Réactivité testée

Humain, souris

Applications

IHC, ELISA

Conjugaison

Non conjugué

Publications(3)

CloneNo.

4D12H7

N° de cat : 60025-2-Ig

Synonymes

CIRBP

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Galerie de données de validation

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  WB analysis of HEK-293 using 60025-2-Ig

  HEK-293 cells were subjected to SDS PAGE followed by western blot with 60025-2-Ig (CIRBP antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

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  IHC staining of human tonsillitis using 60025-2-Ig

  Immunohistochemical analysis of paraffin-embedded human tonsillitis slide using 60025-2-Ig (CIRBP Antibody) at dilution of 1:50.

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Applications publiées

• IHC: See 1 publications below

Informations sur le produit

60025-2-Ig cible CIRBP dans les applications de IHC, ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Réactivité citée: Humain
• Hôte / Isotype: Mouse / IgM
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: CIRBP Protéine recombinante Ag0280
• Nom complet: cold inducible RNA binding protein
• Masse moléculaire calculée: 172 aa, 19 kDa
• Poids moléculaire observé: 19 kDa
• Numéro d’acquisition GenBank: BC000403
• Symbole du gène: CIRBP
• Identification du gène (NCBI): 1153
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Chromatographie d'affinité thiophilique
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

CIRBP, also named as A18HNRNP and CIRP, is a cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. CIRBP is also involved in cap-independent translation upon moderate cold-shock. It acts as a translational activator. CIRBP is a suppressive rather stimulatory effect on proliferation. It acts as a translational repressor. CIRBP is an immortalized gene in murine primary cells. CIRBP promotes assembly of stress granules (SGs), when overexpressed. It is a potential proto-oncogenic proteins upon overexpression.(PMID:19900510) Suppression of CIRBP increased the apoptotic cell population of neural stem cells at moderate low temperature. (PMID:20735994) This antibody can bind the close sequences genes. This antibody is a mouse monoclonal antibody raised against full length CIRBP of human origin.

Publications

Species	Application	Title
		Front Pharmacol; Hypothermic Shock Applied After Perinatal Asphyxia Prevents Retinal Damage in Rats.; Authors - Manuel Rey-Funes
		PLoS One; Cold Shock Proteins Are Expressed in the Retina Following Exposure to Low Temperatures.; Authors - Ignacio M Larrayoz
human	IHC	Ann Dermatol; Expression of Cold-Inducible RNA-Binding Protein in Normal Skin, Actinic Keratosis and Squamous Cell Carcinoma.; Authors - Bo Mi Park

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