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Anticorps Monoclonal anti-CIRBP

CIRBP Monoclonal Antibody for ELISA

Hôte / Isotype

Mouse / IgM

Réactivité testée

Humain, souris

Applications

IHC,ELISA

Conjugaison

Non conjugué

CloneNo.

4D12H7

N° de cat : 60025-2-Ig

Synonymes

Galerie de données de validation

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  • Western Blot (WB) analysis of HEK-293 cells using CIRBP Monoclonal antibody (60025-2-Ig)

    WB analysis of HEK-293 using 60025-2-Ig

    HEK-293 cells were subjected to SDS PAGE followed by western blot with 60025-2-Ig (CIRBP antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

  • Immunohistochemistry (IHC) staining of human tonsillitis tissue using CIRBP Monoclonal antibody (60025-2-Ig)

    IHC staining of human tonsillitis using 60025-2-Ig

    Immunohistochemical analysis of paraffin-embedded human tonsillitis slide using 60025-2-Ig (CIRBP Antibody) at dilution of 1:50.

Applications testées

Dilution recommandée

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Applications publiées

IHCSee 1 publications below

Informations sur le produit

60025-2-Ig cible CIRBP dans les applications de IHC,ELISA et montre une réactivité avec des échantillons Humain, souris

Réactivité Humain, souris
Réactivité citéeHumain
Hôte / Isotype Mouse / IgM
Clonalité Monoclonal
Type Anticorps
Immunogène CIRBP Protéine recombinante Ag0280
Nom complet cold inducible RNA binding protein
Masse moléculaire calculée 172 aa, 19 kDa
Poids moléculaire observé 19 kDa
Numéro d’acquisition GenBankBC000403
Symbole du gène CIRBP
Identification du gène (NCBI) 1153
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Précipitation de l'acide caprylique/du sulfate d'ammonium
Tampon de stockage PBS avec azoture de sodium à 0,1 % et glycérol à 50 % pH 7,3
Conditions de stockageStocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20oC Les 20ul contiennent 0,1% de BSA.

Informations générales

CIRBP, also named as A18HNRNP and CIRP, is a cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. CIRBP is also involved in cap-independent translation upon moderate cold-shock. It acts as a translational activator. CIRBP is a suppressive rather stimulatory effect on proliferation. It acts as a translational repressor. CIRBP is an immortalized gene in murine primary cells. CIRBP promotes assembly of stress granules (SGs), when overexpressed. It is a potential proto-oncogenic proteins upon overexpression.(PMID:19900510) Suppression of CIRBP increased the apoptotic cell population of neural stem cells at moderate low temperature. (PMID:20735994) This antibody can bind the close sequences genes. This antibody is a mouse monoclonal antibody raised against full length CIRBP of human origin.

Publications

SpeciesApplicationTitle
humanIHC

Ann Dermatol

Expression of Cold-Inducible RNA-Binding Protein in Normal Skin, Actinic Keratosis and Squamous Cell Carcinoma.

Authors - Bo Mi Park
View Article