Anticorps Monoclonal anti-IL-1 beta

IL-1 beta Monoclonal Antibody for ELISA

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain, souris et plus (1)

Applications

WB, ELISA

Conjugaison

Non conjugué

Publications(14)

CloneNo.

1C6F12

N° de cat : 60136-1-Ig

Synonymes

IL1- beta, IL1 beta, IL 1 beta, IL 1, Catabolin

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Galerie de données de validation

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Applications publiées

• WB: See 13 publications below
• ELISA: See 1 publications below

Informations sur le produit

60136-1-Ig cible IL-1 beta dans les applications de WB, ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Réactivité citée: rat, Humain, souris
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: IL-1 beta Protéine recombinante Ag10295
• Nom complet: interleukin 1, beta
• Masse moléculaire calculée: 269 aa, 31 kDa
• Numéro d’acquisition GenBank: BC008678
• Symbole du gène: IL1B
• Identification du gène (NCBI): 3553
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine G
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

Interleukin-1 is a pro-inflammatory cytokine with multiple biological effects. The IL-1 gene family encodes three proteins: IL-1α, IL-1β and their naturally occurring inhibitor Il-1RN. IL-1 Beta(IL-1β), mainly produced by blood monocytes and tissue macrophages, has been implicated in mediating both acute and chronic inflammation. IL-1β is known to be involved in a variety of cellular activities, including cell proliferation, differentiation and apoptosis. IL-1β is emerging as a key mediator of carcinogenesis that characterizes host-environment interactions. Human IL-1β is synthesized as a 31 kDa precursor. To gain activity, the precursor must be cleaved by caspase-1 between Asp116 and Ala117 to yield a 17 kDa mature form.

Publications

Species	Application	Title
human	WB	Nat Immunol; RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway.; Authors - Xiaqiong Wang
human,mouse	WB	Nat Cell Biol; Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity.; Authors - Yi Huang
human,mouse	WB	Nat Commun; CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation.; Authors - Tiantian Tang
human	WB	EMBO Mol Med; Tranilast directly targets NLRP3 to treat inflammasome-driven diseases.; Authors - Yi Huang
human	WB	Oncotarget; Loss of AIM2 expression promotes hepatocarcinoma progression through activation of mTOR-S6K1 pathway.; Authors - Xiaomin Ma
rat	WB	J Ethnopharmacol; Yi-shen-hua-shi granules modulate immune and inflammatory damage via the ALG3/PPARγ/NF-κB pathway in the treatment of immunoglobulin a nephropathy; Authors - Rongjia Xu

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