Anticorps Monoclonal anti-PD-L1/CD274

PD-L1/CD274 Monoclonal Antibody for FC

Hôte / Isotype

Mouse / IgG2b, kappa

Réactivité testée

Humain

Applications

FC

Conjugaison

CoraLite® Plus 647 Fluorescent Dye

CloneNo.

29E.2A3

N° de cat : CL647-65081

Synonymes

CD274, PD-L1, PD L1, hPD-L1, B7-H1



Applications testées

Résultats positifs en cytométrielymphocytes de sang périphérique humain,

Dilution recommandée

ApplicationDilution
This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 μl per 10^6 cells in a 100 µl suspension or 5 μl per 100 µl of whole blood.
Sample-dependent, check data in validation data gallery

Informations sur le produit

CL647-65081 cible PD-L1/CD274 dans les applications de FC et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Mouse / IgG2b, kappa
Clonalité Monoclonal
Type Anticorps
Immunogène PD-L1 humain pleine longueur
Nom complet CD274 molecule
Numéro d’acquisition GenBankBC069381
Symbole du gène PD-L1
Identification du gène (NCBI) 29126
Conjugaison CoraLite® Plus 647 Fluorescent Dye
Excitation/Emission maxima wavelengths654 nm / 674 nm
Forme Liquide
Méthode de purification Purification par affinité
Tampon de stockage PBS with 0.09% sodium azide and 0.5% BSA
Conditions de stockageStore at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Informations générales

Programmed cell death ligand 1 (PD-L1, CD274, or B7-H1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. PD-L1 is suggested as a negative regulator of T and B cell, and plays important role in mediating tolerance of lymphocytes to self-antigens. It is also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PD-1-independent manner.

Protocole

Product Specific Protocols
FC protocol for CL Plus 647 PD-L1/CD274 antibody CL647-65081Download protocol
Standard Protocols
Click here to view our Standard Protocols
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