Home
Products
Primary Antibodies
Flow Cytometry Antibodies
Anti-Human CD89 Rabbit Recombinant Antibody (98105-1-RR)

Anti-Human CD89 Rabbit Recombinant Antibody

CD89 Uni-rAb^® Recombinant Antibody for FC

Cat No. 98105-1-RR

Clone No. 241426E3

Review Product

Download datasheet

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

Synonyms

241426E3, FCAR, IgA Fc receptor

Formulation: PBS, Azide

PBS, Azide

PBS Only

Conjugate: Unconjugated

Unconjugated

Size/Concentration:

SKU:

-/ -

Freight/Packing: -

Quantity

- +

Request bulk or custom quote

Proteintech Guarantee

Filter: AllFCAffinity

FC experiment of human peripheral blood leukocytes using 98105-1-RR
1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human CD89 Rabbit Recombinant Antibody (98105-1-RR, Clone: 241426E3) or 0.25 ug Isotype Control, and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). Cells were co-stained with CoraLite® Plus 647 Anti-Human CD16 (3G8). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.
This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
FC experiment of human peripheral blood leukocytes using 98105-1-RR
1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human CD89 Rabbit Recombinant Antibody (98105-1-RR, Clone: 241426E3) (red) or 0.25 ug Isotype Control (blue), and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.
This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
Affinity and Kinetic Characterization of 98105-1-RR
Biolayer interferometry (BLl) kinetic assays of 98105-1-RR against Human CD89 were performed. The affinity constant is 2.81 nM.
This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

Able AI

What's the best dilution for CD89 in ?

Overview

Tested Applications
Product Information
Protocols

Print datasheet

MSDS SDS

Tested Applications

Positive FC detected in

human peripheral blood leukocytes

Recommended dilution

Application	Dilution
Flow Cytometry (FC)	FC : 0.25 ug per 10^6 cells in 100 μl suspension
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

98105-1-RR targets CD89 in FC applications and shows reactivity with human samples.

Tested Reactivity	human
Host / Isotype	Rabbit / IgG
Class	Recombinant
Type	Antibody
Immunogen	Recombinant Protein Predict reactive species
Full Name	Fc fragment of IgA, receptor for
Calculated Molecular Weight	287 aa, 32 kDa
GenBank Accession Number	BC027953
Gene Symbol	CD89
Gene ID (NCBI)	2204
RRID	AB_3672252
Conjugate	Unconjugated
Form	Liquid
Purification Method	Protein A purification
UNIPROT ID	P24071
Storage Buffer	PBS with 0.09% sodium azide, pH 7.3.
Storage Conditions	Store at 2 - 8°C. Stable for one year after shipment.

Background Information

FcαRI (CD89) is a member of the Fc receptor immunoglobulin superfamily, constitutively expressed on cells of the myeloid lineage like neutrophils, eosinophils, monocytes, macrophages, and platelets (PMID: 28103138). CD89 expression and activation are increased in human blood phagocytes following bacterial infection, together with increased expression and association of FcRγ with CD89 (PMID: 34756952). CD89 binds both subclasses of IgA (IgA1 and IgA2) with moderate affinity, but also binds other molecules such as TfR1, C-reactive protein and bacterial ligands. CD89 represents an effective target molecule for immunotherapy mediated by bispecific antibodies (PMID: 37081893).