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Anti-Human CD89 Rabbit Recombinant Antibody, PBS Only (98105-1-PBS)

Anti-Human CD89 Rabbit Recombinant Antibody, PBS Only

Name: Anti-Human CD89 Rabbit Recombinant Antibody, PBS Only, 1mg
Brand: Proteintech
SKU: 98105-1-PBS-1MG

CD89 Uni-rAb^® Recombinant Antibody for FC

Cat No. 98105-1-PBS

Clone No. 241426E3

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Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

Synonyms

241426E3, FCAR, IgA Fc receptor

Formulation: PBS Only

PBS, Azide

PBS Only

Conjugate: Unconjugated

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FC experiment of human peripheral blood leukocytes using 98105-1-RR (same clone as 98105-1-PBS)
1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human CD89 Rabbit Recombinant Antibody (98105-1-RR, Clone: 241426E3) or 0.25 ug Isotype Control, and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). Cells were co-stained with CoraLite® Plus 647 Anti-Human CD16 (3G8). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98105-1-PBS in a different storage buffer formulation.
This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
×
1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human CD89 Rabbit Recombinant Antibody (98105-1-RR, Clone: 241426E3) or 0.25 ug Isotype Control, and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). Cells were co-stained with CoraLite® Plus 647 Anti-Human CD16 (3G8). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98105-1-PBS in a different storage buffer formulation.
FC experiment of human peripheral blood leukocytes using 98105-1-RR (same clone as 98105-1-PBS)
1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human CD89 Rabbit Recombinant Antibody (98105-1-RR, Clone: 241426E3) (red) or 0.25 ug Isotype Control (blue), and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98105-1-PBS in a different storage buffer formulation.
This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
×
1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human CD89 Rabbit Recombinant Antibody (98105-1-RR, Clone: 241426E3) (red) or 0.25 ug Isotype Control (blue), and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98105-1-PBS in a different storage buffer formulation.
Affinity and Kinetic Characterization of 98105-1-RR
Biolayer interferometry (BLl) kinetic assays of 98105-1-RR against Human CD89 were performed. The affinity constant is 2.81 nM.
This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Overview

Tested Applications
Product Information

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Product Information

98105-1-PBS targets CD89 in FC applications and shows reactivity with human samples.

Tested Reactivity	human
Host / Isotype	Rabbit / IgG
Class	Recombinant
Type	Antibody
Immunogen	Recombinant Protein Predict reactive species
Full Name	Fc fragment of IgA, receptor for
Calculated Molecular Weight	287 aa, 32 kDa
GenBank Accession Number	BC027953
Gene Symbol	CD89
Gene ID (NCBI)	2204
RRID	AB_3672252
Conjugate	Unconjugated
Form	Liquid
Purification Method	Protein A purification
UNIPROT ID	P24071
Storage Buffer	PBS only, pH 7.3.
Storage Conditions	Store at -80°C.

Background Information

FcαRI (CD89) is a member of the Fc receptor immunoglobulin superfamily, constitutively expressed on cells of the myeloid lineage like neutrophils, eosinophils, monocytes, macrophages, and platelets (PMID: 28103138). CD89 expression and activation are increased in human blood phagocytes following bacterial infection, together with increased expression and association of FcRγ with CD89 (PMID: 34756952). CD89 binds both subclasses of IgA (IgA1 and IgA2) with moderate affinity, but also binds other molecules such as TfR1, C-reactive protein and bacterial ligands. CD89 represents an effective target molecule for immunotherapy mediated by bispecific antibodies (PMID: 37081893).