Recombinant Mouse Fas/TNFRSF6/CD95 protein (mFc Tag)
Species
Mouse
Purity
>90 %, SDS-PAGE
Tag
mFc Tag
Activity
not tested
Cat no : Eg1375
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <1.0 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Mouse Fas/TNFRSF6/CD95 protein Gln22-Arg169 (Accession# P25446) with a mouse IgG Fc tag at the C-terminus. |
| GeneID | 14102 |
| Accession | P25446 |
| PredictedSize | 43.2 kDa |
| SDS-PAGE | |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
FAS, also named as CD95, APO-1, APT1, FAS1 and TNFRSF6, is a receptor for TNFSF6/FASLG. It is a cell surface receptor belonging to the TNF receptor superfamily, can mediate apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains, leading to the formation of the death-inducing signaling complex (DISC). FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.
References:
1. Hu, Liying et al. Frontiers in cellular and infection microbiology vol. 15 (2025) 1561102. 2. Strasser, Andreas et al. Immunity vol. 30,2 (2009): 180-92. 3. Dockrell, D H. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases vol. 9,8 (2003): 766-79.