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Recombinant Human CD37 protein (rFc Tag)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg1764

Validation Data Gallery

  • Purity of Recombinant Human CD37 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

    Purity of Recombinant Human CD37 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

Product Information

Purity >90 %, SDS-PAGE
Endotoxin <0.1 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Human CD37 protein Arg112-Asn241 (Accession# P11049-1) with a rabbit IgG Fc tag at the C-terminus.
GeneID 951
Accession P11049-1
PredictedSize 44.2 kDa
SDS-PAGE 45-60 kDa, reducing (R) conditions
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

CD37 is a membrane protein of the tetraspanin superfamily which are characterized by the presence of four conserved transmembrane regions. CD37 is a tetraspanin expressed prominently on the surface of B cells. Many of these members are expressed on leukocytes and have been implicated in signal transduction, cell-cell interactions, and cellular activation and development. CD37 plays a role in B-cell function, and may also play a role in T-cell-B-cell interactions. CD37 is crucial in regulating B cell survival, shaping immune response, and immune evasion.

References:

1.Hemler ME. (2005) Nat Rev Mol Cell Biol. 6(10):801-11.
2.Bobrowicz M, et al. (2020) Int J Mol Sci. 21(24):9531.
3.Knobeloch KP, et al. (2000) Mol Cell Biol. 20(15):5363-9.
4.Schaper F, van Spriel AB. (2018) Front Immunol. 9:1185.