Recombinant Human NKG2C/CD159c protein (rFc Tag)
Species
Human
Purity
>85 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg1953
Validation Data Gallery
Product Information
| Purity | >85 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human NKG2C protein Ile94-Leu231 (Accession# P26717) with a rabbit IgG Fc tag at the N-terminus. |
| GeneID | 3822 |
| Accession | P26717 |
| PredictedSize | 43.0 kDa |
| SDS-PAGE | 47-60 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
The NKG2C is a heterodimeric receptor, consisted of two type II proteins and is a member of the C-type lectin-like family. Similar to the other activating NKG2 receptors, the NKG2C has a negatively charged residue (either a lysine or an arginine) in its transmembrane domain. NKG2C is an activating receptor that recognizes HLA-E in complex with leader sequence peptides. The gene encoding NKG2C (killer-cell lectin-like receptor C2, KLRC2) is present at different copy numbers in the genomes of different individuals.
References:
1. Siemaszko, Jagoda et al. Archivum immunologiae et therapiae experimentalis vol. 71,1 9. 10 Mar. 2023, 2. Cao, Kai et al. Frontiers in immunology vol. 9 2444. 23 Oct. 2018.