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Recombinant Mouse Beta-2-Microglobulin protein (rFc Tag)

Species

Mouse

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg3086

Validation Data Gallery

  • Purity of Recombinant Mouse Beta-2-Microglobulin was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse Beta-2-Microglobulin was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

Product Information

Purity >90 %, SDS-PAGE
Endotoxin <0.1 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Mouse Beta-2-Microglobulin protein Ile21-Met119 (Accession# P01887) with a rabbit IgG Fc tag at the C-terminus.
GeneID 12010
Accession P01887
PredictedSize 37.7 kDa
SDS-PAGE 37-42 kDa, reducing (R) conditions
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

Beta-2-microglobulin (B2M) is a component of MHC class I molecules, which are present on the surface of nearly all nucleated cells. It can be found in body fluids under physiologic conditions as a result of shedding from cell surfaces or intracellular release. B2M has various biological functions, including antigen presentation. Investigations reveal that increased synthesis and release of B2M are present in several malignant diseases.

References:

1. Gao Y, Hong Y, et al. (2023) Cell. 186(5):1026-1038.e20. 
2. Enzan N, Matsushima S, et al. (2023) Circ Res. 132(9):1110-1126. 
3. Jheng JR, DesJardin JT, et al. (2024) scler Thromb Vasc Biol. 44(7):1570-1583. 
4. Zhao Y, Zheng Q, et al.  (2023) Nat Neurosci. 26(7):1170-1184.