Recombinant Human Serpin A4/Kallistatin protein (rFc Tag)
Species
Human
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg4707
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human Serpin A4 protein Gln21-Pro427 (Accession# P29622) with a rabbit IgG Fc tag at the N-terminus. |
| GeneID | 5267 |
| Accession | P29622 |
| PredictedSize | 73.6 kDa |
| SDS-PAGE | 70-90 kDa and 160-220 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
Serpina family A member 4 (SERPINA4), also known as KAL, KST, or kallistatin, was first identified as a tissue kallikrein-binding protein in the 1900s. SERPINA4 is a novel anti-angiogenesis agent, which exerts multiple effects on inflammation, angiogenesis, and tumor growth.
References:
1. Chao, J et al. The Journal of biological chemistry vol. 265,27 (1990): 16394-401. 2. Chao, J et al. The Biochemical journal vol. 239,2 (1986): 325-31. 3. Wang, Chrong-Reen et al. Arthritis and rheumatism vol. 52,4 (2005): 1319-24.