Recombinant Human SEMA3C protein (rFc Tag)
Species
Human
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg4979
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human SEMA3C protein Gly21-Ser738 (Accession# Q99985) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 10512 |
| Accession | Q99985 |
| PredictedSize | 107.4 kDa |
| SDS-PAGE | 52-56 kDa and 110-130 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
SEMA3C (Semaphorin 3C) is associated with tumor progression and poor prognosis across multiple tumor types, including pancreatic, gastric, prostate, and breast cancer, as well as glioma. It is worth noting that full-length SEMA3C has also been reported as a tumor suppressor factor by suppressing tumor lymphangiogenesis and metastasis.
References:
1. Hao, Jing et al. Nature communications vol. 14,1 2262. 20 Apr. 2023. 2. Xiao, Siyu et al. Oncogene vol. 44,39 (2025): 3679-3693. 3. Liu, Ruoyan et al. Frontiers in oncology vol. 9 1035. 9 Oct. 2019.