Recombinant Mouse MAG protein (rFc Tag)
Species
Mouse
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg6788
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Mouse MAG protein Gly20-Pro516 (Accession# P20917-1) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 17136 |
| Accession | P20917-1 |
| PredictedSize | 80.4 kDa |
| SDS-PAGE | 90-120 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
Myelin-associated glycoprotein (MAG) is a type I trans-membrane glycoprotein that belongs to the immunoglobulin (Ig) super-family. It contains five extracellular Ig-like domains, a single trans-membrane segment and one of two alternatively spliced cytoplasmic tails. MAG is expressed exclusively by myelinating glia—oligodendrocytes in the central nervous system (CNS) and Schwann cells in the peripheral nervous system (PNS)—where it localises to the periaxonal, non-compacted regions of the myelin sheath.
References:
Schnaar, Ronald L, and Pablo H H Lopez. Journal of neuroscience research vol. 87,15 (2009): 3267-76.