Recombinant Human MFAP5 protein (rFc Tag)
Species
Human
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg8764
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human MFAP5 protein Ile22-Leu173 (Accession# Q13361-1) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 8076 |
| Accession | Q13361-1 |
| PredictedSize | 42.9 kDa |
| SDS-PAGE | kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
MFAP5 (microfibril-associated protein 5), also known as MAGP-2, is a secreted extracellular matrix glycoprotein, not a membrane protein in the traditional sense. As a component of microfibrils, it is typically secreted into the extracellular space and assembles onto fibrillin-containing microfibrils, mediating cell-fibril adhesion through binding to integrin αVβ3. Its main functions include elastic fiber assembly, mediating cell signaling (such as the MAPK/ERK pathway), and regulating cell behavior in development and disease.
References:
1. Duan, Yi et al. Oncogene vol. 42,25 (2023): 2061-2073. 2. Li, Jian-Hui et al. Journal of experimental & clinical cancer research : CR vol. 38,1 476. 27 Nov. 2019 3. Li, Qingmei et al. Biochemical and biophysical research communications vol. 507,1-4 (2018): 51-58.