Product Information
33759-1-PBS targets AGK in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag37404 Product name: Recombinant human AGK protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 93-423 aa of BC022777 Sequence: MDVTIVKTDYEGQAKKLLELMENTDVIIVAGGDGTLQEVVTGVLRRTDEATFSKIPIGFIPLGETSSLSHTLFAESGNKVQHITDATLAIVKGETVPLDVLQIKGEKEQPVFAMTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFSTLKEWPQTHQASISYTGPTERPPNEPEETPVQRPSLYRRILRRLASYWAQPQDALSQEVSPEVWKDVQLSTIELSITTRNNQLDPTSKEDFLNICIEPDTISKGDFITIGSRKVRNPKLHVEGTECLQASQCTLLIPEGAGGSFSIDSEEYEAMPVEVKLLPRKLQFFCDPRKREQMLTSPTQ Predict reactive species |
| Full Name | acylglycerol kinase |
| Calculated Molecular Weight | 47 kDa |
| Observed Molecular Weight | 47 kDa |
| GenBank Accession Number | BC022777 |
| Gene Symbol | AGK |
| Gene ID (NCBI) | 55750 |
| RRID | AB_3743070 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity Purification |
| UNIPROT ID | Q53H12 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
AGK (Acylglycerol Kinase), also designated as MULK (multi-substrate lipid kinase), is a member of the AGK protein family and functions as a lipid kinase localized to the inner mitochondrial membrane. This protein exhibits a distinctive dual functionality. First, acting as a lipid kinase, it catalyzes the phosphorylation of monoacylglycerol and diacylglycerol to yield lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively, thereby participating in phospholipid metabolism and lipid-mediated signal transduction. Second, independent of its kinase activity, AGK serves as a core subunit of the TIM22 complex, where it is responsible for the translocation and insertion of multiple mitochondrial carrier proteins (e.g., ANT1) into the inner mitochondrial membrane.
