ALDH1A1 Antibody 14 Publications

Rabbit Polyclonal| Catalog number: 15910-1-AP

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Freight/Packing

Con: 45 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse liver tissue, HL-60 cells, human liver tissue, K-562 cells

Positive IP detected in:
mouse liver tissue

Positive IHC detected in:
human testis tissue, human eye tissue, human liver tissue, human testis tissue, mouse testis tissue

Positive IF detected in:
HepG2 cells, mouse testis tissue

Recommended dilution:
WB : 1:500-1:3000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:100-1:400
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
aldehyde dehydrogenase 1 family, member A1

Calculated molecular weight:
501aa,55 kDa

Observed molecular weight:
50-55 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ALDH1A1

Synonyms
ALDC, ALDH E1, ALDH1, ALDH11, ALDH1A1, ALHDII, PUMB1, RALDH 1, RALDH1, Retinal dehydrogenase 1
Background

ALDH1A1(Aldehyde dehydrogenase family 1 member A1 ), also named as ALDC, ALDH1 and PUMB1, belongs to the aldehyde dehydrogenase family. The ALDH1A1 gene encodes a liver cytosolic isoform of acetaldehyde dehydrogenase, an enzyme involved in the major pathway of alcohol metabolism after alcohol dehydrogenase. ALDH1A1 plays a critical role in protection against oxidative stress-induced cytotoxicity in lens epithelial cells(PMID:19296407). And it is important for multiple biological activities including drug resistance, cell differentiation, and oxidative stress response(PMID:19025616). As a novel cancer stem cell marker, ALDH1A1 can be used for tumors whose corresponding normal tissues express ALDH1 in relatively restricted or limited levels such as breast, lung, ovarian or colon cancer(PMID: 20422001).


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