Validation Data Gallery
|Positive WB detected in||HeLa cells, A431 cells, mouse uterus tissue|
|Positive IP detected in||HeLa cells|
|Positive IHC detected in||human ovary tumor tissue, human breast cancer tissue, human kidney tissue, human lung cancer tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Positive IF detected in||HeLa cells|
|Western Blot (WB)||WB : 1:1000-1:8000|
|Immunoprecipitation (IP)||IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB|
|Immunohistochemistry (IHC)||IHC : 1:50-1:500|
|Immunofluorescence (IF)||IF : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
10479-2-AP targets Annexin A11 in WB, IP, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Annexin A11 fusion protein Ag0729|
|Full Name||annexin A11|
|Calculated molecular weight||56 kDa|
|Observed molecular weight||56-60 kDa|
|GenBank accession number||BC007564|
|Gene ID (NCBI)||311|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
Annexin A11 (Anxa11) is one member of annexins that are Ca2+-regulated phospholipid-binding proteins. Annexin A11 plays an important role in cell division, differentiation, apoptosis, vesicle trafficking and Ca2+ signaling. Annexin A11 dysregulation is involved in the progression, drug-resistance, recurrence of systemic autoimmune disease and cancer.
|Product Specific Protocols|
|WB protocol for Annexin A11 antibody 10479-2-AP||Download protocol|
|IHC protocol for Annexin A11 antibody 10479-2-AP||Download protocol|
|IF protocol for Annexin A11 antibody 10479-2-AP||Download protocol|
|IP protocol for Annexin A11 antibody 10479-2-AP||Download protocol|
|Click here to view our Standard Protocols|
Sci Transl Med
Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis.
A Novel Multisystem Proteinopathy Caused by a Missense ANXA11 Variant.
ANXA11 regulates the tumorigenesis, lymph node metastasis and 5-fluorouracil sensitivity of murine hepatocarcinoma Hca-P cells by targeting c-Jun.
Annexin A11 knockdown inhibits in vitro proliferation and enhances survival of Hca-F cell via Akt2/FoxO1 pathway and MMP-9 expression.
Genetic screening of ANXA11 revealed novel mutations linked to amyotrophic lateral sclerosis.
Ann Clin Transl Neurol
Adult-onset dominant muscular dystrophy in Greek families caused by Annexin A11