Product Information
23908-1-PBS targets ARNTL2 in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag21003 Product name: Recombinant human ARNTL2 protein Source: e coli.-derived, PET30a Tag: 6*His Domain: 391-578 aa of BC000172 Sequence: SQWFSFTNPWTKELEYIVSVNTLVLGHSEPGEASFLPCSSQSSEESSRQSCMSVPGMSTGTVLGAGSIGTDIANEILDLQRLQSSSYLDDSSPTGLMKDTHTVNCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL Predict reactive species |
| Full Name | aryl hydrocarbon receptor nuclear translocator-like 2 |
| Calculated Molecular Weight | 636 aa, 71 kDa |
| Observed Molecular Weight | 70 kDa |
| GenBank Accession Number | BC000172 |
| Gene Symbol | ARNTL2 |
| Gene ID (NCBI) | 56938 |
| RRID | AB_3742097 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen Affinity purified |
| UNIPROT ID | Q8WYA1 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
ARNTL2 (Aryl Hydrocarbon Receptor Nuclear Translocator Like 2), also known as BMAL2 (Brain and Muscle ARNT-Like 2), is a core component of the circadian clock genes within the PAS (PER, ARNT, SIM) superfamily (PMID: 27671790). ARNTL2 has also been demonstrated to play an essential role in various tumors, it is associated with poor survival and immune infiltration in clear cell renal cell carcinoma and triple-Negative Breast Cancer (PMID: 34785930). Besides, ARNTL2 has also been found to promote metastasis of colon carcinoma and estrogen Receptor-Negative Breast Cancer (PMID: 27656887).
