|Positive WB detected in||HL-60 cells, human placenta tissue, rat spleen tissue, THP-1 cells, U-937 cells|
|Western Blot (WB)||WB : 1:5000-1:50000|
|Sample-dependent, check data in validation data gallery|
67494-1-Ig targets ASC/TMS1 in WB, IHC, IF, CoIP, ELISA applications and shows reactivity with Human, rat samples.
|Tested Reactivity||Human, rat|
|Host / Isotype||Mouse / IgG1|
|Immunogen||ASC/TMS1 fusion protein Ag28424|
|Full Name||PYD and CARD domain containing|
|Calculated molecular weight||25 kDa|
|Observed molecular weight||22-25 kDa|
|GenBank accession number||BC004470|
|Gene ID (NCBI)||29108|
|Purification Method||Protein A purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.|
PYCARD , also known as ASC or TMS1, is a 195 amino acid protein containing an N-terminal Pyrin-like domain (PYD) and an 87 residue C-terminal Caspase-associated recruitment domain (CARD). It promotes caspase-mediated apoptosis which is mediated predominantly through the activation of caspase-9.
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