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Alpha-1-Antitrypsin Recombinant antibody, PBS Only
Alpha-1-Antitrypsin Uni-rAbTM Recombinant Antibody for WB, FC (Intra), Indirect ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human
Applications
WB, FC (Intra), Indirect ELISA
Conjugate
Unconjugated
CloneNo.
230109A8
Cat no : 82918-1-PBS
Synonyms
Validation Data Gallery
Product Information
82918-1-PBS targets Alpha-1-Antitrypsin in WB, FC (Intra), Indirect ELISA applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Immunogen | Alpha-1-Antitrypsin fusion protein Ag9369 |
Full Name | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 |
Calculated Molecular Weight | 418 aa, 47 kDa |
Observed Molecular Weight | 47 kDa |
GenBank Accession Number | BC015642 |
Gene Symbol | Alpha 1-Antitrypsin |
Gene ID (NCBI) | 5265 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
SERPINA1 is the gene for a protein called alpha-1-antitrypsin (AAT), which is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. AAT is a glycoprotein synthesized primarily by hepatocytes, with smaller amountssynthesized by intestinal epithelial cells, neutrophils, pulmonary alveolar cells and macrophages. AAT is the most abundant, endogenous serine protease inhibitor in blood circulation and it has been implicated in regulating vital fluid phase biological events such as blood coagulation, fibrinolysis, complement activation, apoptosis, reproduction, tumor progression and inflammatory response. The primary function of AAT is thought to be the inactivation of neutrophil elastase and other endogenous serine proteases. Defects in SERPINA1 can cause emphysema or liver disease.