Mouse Angiopoietin-2 Recombinant antibody, PBS Only

Angiopoietin-2 {ptg:Brand} Recombinant Antibody for WB, IHC, IP, ELISA
Cat No. 83816-1-PBS
Clone No.240760D5

Host / Isotype

Rabbit / IgG

Reactivity

mouse

Applications

WB, IHC, IP, ELISA

Angpt2, angiopoietin 2, Ang2, Ang 2, Agpt2

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

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Product Information

83816-1-PBS targets Angiopoietin-2 in WB, IHC, IP, ELISA applications and shows reactivity with mouse samples.

Tested Reactivity mouse
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Recombinant protein Predict reactive species
Full Name angiopoietin 2
Calculated Molecular Weight56KD
Observed Molecular Weight 68kDa
GenBank Accession NumberNM_007426.4
Gene Symbol Angpt2
Gene ID (NCBI) 11601
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDO35608
Storage Buffer PBS only , pH 7.3
Storage ConditionsStore at -80°C.

Background Information

Angiopoietin-2 (ANGPT2, ANG-2) is as a regulator of vessel enlargement, and ANGPT2 inhibition prevented pathological vessel enlargement (PMID: 34758631). ANGPT2 destabilizes vessels and promotes angiogenesis through antagonism of ANGPT1 (PMID: 34758631). Ang2 was initially identified by homology with Ang1 and is expressed predominantly by endothelial cells, where it is stored in intracellular secretory granules called Weibel-Palade bodies (WPB) and promptly released after endothelium activation. Like Ang1, Ang2 binds to Tie2 receptor, but with different pathophysiological effects. While Ang1 fosters endothelial stabilization, Ang2 can antagonize Ang1, blocking Tie2 activation and leading to vessel destabilization (PMID: 31756341).

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