Product Information
33022-1-PBS targets B3GALT5 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag37977 Product name: Recombinant human B3GALT5 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 29-310 aa of BC104862 Sequence: NPFKEQSFVYKKDGNFLKLPDTDCRQTPPFLVLLVTSSHKQLAERMAIRQTWGKERTVKGKQLKTFFLLGTTSSAAETKEVDQESQRHGDIIQKDFLDVYYNLTLKTMMGIEWVHRFCPQAAFVMKTDSDMFINVDYLTELLLKKNRTTRFFTGFLKLNEFPIRQPFSKWFVSKSEYPWDRYPPFCSGTGYVFSGDVASQVYNVSKSVPYIKLEDVFVGLCLERLNIRLEELHSQPTFFPGGLRFSVCLFRRIVACHFIKPRTLLDYWQALENSRGEDCPPV Predict reactive species |
| Full Name | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 |
| Calculated Molecular Weight | 310 aa, 36 kDa |
| Observed Molecular Weight | 44 kDa |
| GenBank Accession Number | BC104862 |
| Gene Symbol | B3GALT5 |
| Gene ID (NCBI) | 10317 |
| RRID | AB_3742824 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity Purification |
| UNIPROT ID | Q9Y2C3 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
B3GALT5 (β-1,3-galactosyltransferase 5) is a key glycosyltransferase enzyme. It is responsible for catalyzing the synthesis of the terminal glycan structure, the sialyl Lewis X antigen. This antigen serves as an important ligand for selectin family proteins, mediating cell adhesion in both physiological and pathological processes. Its core function lies in regulating cell migration. In immunology, it influences lymphocyte homing; in oncology, its aberrant upregulation promotes the synthesis of sLe^x, leading to the adhesion of cancer cells to vascular endothelium via the "selectin-ligand" recognition system. This represents a critical initial step in tumor hematogenous metastasis, such as to the liver or lungs.
