Product Information
16586-1-PBS targets B3GAT3 in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag8362 Product name: Recombinant human B3GAT3 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 1-335 aa of BC007906 Sequence: MKLKLKNVFLAYFLVSIAGLLYALVQLGQPCDCLPPLRAAAEQLRQKDLRISQLQAELRRPPPAPAQPPEPEALPTIYVVTPTYARLVQKAELVRLSQTLSLVPRLHWLLVEDAEGPTPLVSGLLAASGLLFTHLVVLTPKAQRLREGEPGWVHPRGVEQRNKALDWLRGRGGAVGGEKDPPPPGTQGVVYFADDDNTYSRELFEEMRWTRGVSVWPVGLVGGLRFEGPQVQDGRVVGFHTAWEPSRPFPVDMAGFAVALPLLLDKPNAQFDSTAPRGHLESSLLSHLVDPKDLEPRAANCTRVLVWHTRTEKPKMKQEEQLQRQGRGSDPAIEV Predict reactive species |
| Full Name | beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I) |
| Calculated Molecular Weight | 335 aa, 37 kDa |
| Observed Molecular Weight | 37-40 kDa |
| GenBank Accession Number | BC007906 |
| Gene Symbol | B3GAT3 |
| Gene ID (NCBI) | 26229 |
| RRID | AB_3741889 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | O94766 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
B3GAT3 (Beta-1,3-Glucuronyltransferase 3), also known as Glucuronosyltransferase I (GlcAT-I), is an enzyme encoded by the B3GAT3 gene. This enzyme belongs to the glycosyltransferase family and catalyzes the transfer of glucuronic acid (GlcA) from UDP-GlcA to the terminal galactose residue of the linkage region tetrasaccharide (GlcA-Gal-Gal-Xyl-) during the biosynthesis of proteoglycans. The addition of glucuronic acid is a critical step in forming the glycosaminoglycan-protein linkage region, which serves as the attachment site for heparan sulfate and chondroitin sulfate chains. Mutations in the B3GAT3 gene cause a rare autosomal recessive disorder known as linkeropathy or B3GAT3-related multiple joint dislocations.
