BCL2 Antibody 291 Publications

Rabbit Polyclonal| Catalog number: 12789-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 45 μg/150 μl

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Species specificity:
human, fish, guinea pig, N. guentheri, rabbit, sheep

Positive WB detected in:
HL-60 cells, Jurkat cells, U-937 cells

Positive IP detected in:
HL-60 cells, HepG2 cells, MCF-7 cells

Positive IHC detected in:
human tonsillitis tissue, human breast cancer tissue, human colon cancer tissue, human lung cancer tissue, human lymphoma tissue, rat brain tissue

Positive FC detected in:
Jurkat cells

Recommended dilution:
WB : 1:1000-1:4000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:50-1:300

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
B-cell CLL/lymphoma 2

Calculated molecular weight:
26 kDa

Observed molecular weight:
25-30 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
BCL2

Synonyms
Apoptosis regulator Bcl 2, B cell CLL/lymphoma 2, BCL2, BCL-2, Oncogene B cell leukemia 2
Background

BCL2 belongs to the Bcl-2 family. It suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. BCL2 regulates cell death by controlling the mitochondrial membrane permeability (PMID: 10365962). It appears to function in a feedback loop system with caspases. BCL2 inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (PMID: 10444588). This antibody is not suitable for rat and mouse species.


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