|Positive WB detected in||human brain tissue, HeLa cells|
|Positive FC detected in||HeLa cells|
|Western Blot (WB)||WB : 1:200-1:1000|
|Sample-dependent, check data in validation data gallery|
19791-1-AP targets BRCA2 in WB, IHC, FC,ELISA applications and shows reactivity with human samples.
|Host / Isotype||Rabbit / IgG|
|Full Name||breast cancer 2, early onset|
|Calculated molecular weight||384 kDa|
|Observed molecular weight||384 kDa|
|GenBank accession number||NM_000059|
|Gene ID (NCBI)||675|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
BRCA2, also named as FACD and FANCD1, is involved in double-strand break repair and/or homologous recombination. BRCA2 may participate in S phase checkpoint activation. Defects in BRCA2 are a cause of genetic susceptibility to breast cancer (BC) which also called susceptibility to familial breast-ovarian cancer type 2 (BROVCA2).
J Hematol Oncol
SPAG5 upregulation contributes to enhanced c-MYC transcriptional activity via interaction with c-MYC binding protein in triple-negative breast cancer.
Ann Transl Med
miR-1245a promotes the proliferation and invasion of colon adenocarcinoma by targeting BRCA2.
Cancer Biol Ther
A novel BRCA2 mutation in prostate cancer sensitive to combined radiotherapy and androgen deprivation therapy.
Flavone protects HBE cells from DNA double-strand breaks caused by PM2.5.
DNA repair gene expression is increased in HPV positive head and neck squamous cell carcinomas.
Downregulation of Mitochondrial Single Stranded DNA Binding Protein (SSBP1) Induces Mitochondrial Dysfunction and Increases the Radiosensitivity in Non-Small Cell Lung Cancer Cells.