C10orf88 Polyclonal antibody

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  IP experiment of SH-SY5Y using 26026-1-AP

  IP result of anti-C10orf88 (IP:26026-1-AP, 4ug; Detection:26026-1-AP 1:600) with SH-SY5Y cells lysate 1920 ug.

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  IP experiment of HEK-293 using 26026-1-AP

  IP result of anti-C10orf88 (IP:26026-1-AP, 4ug; Detection:26026-1-AP 1:600) with HEK-293 cells lysate 1600 ug.

C10orf88 Polyclonal Antibody for IP, ELISA

Cat No. 26026-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IP, ELISA

Synonyms

ATPase PAAT, EC:3.6.1.-, PAAT, Protein associated with ABC transporters

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Tested Applications

• Positive IP detected in: HEK-293 cells, SH-SY5Y cells

Recommended dilution

• Immunoprecipitation (IP): IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

26026-1-AP targets C10orf88 in IP, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: C10orf88 fusion protein Ag22971
• Full Name: chromosome 10 open reading frame 88
• Calculated Molecular Weight: 445 aa, 49 kDa
• Observed Molecular Weight: 49 kDa
• GenBank Accession Number: BC032645
• Gene Symbol: C10orf88
• Gene ID (NCBI): 80007
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q9H8K7
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

C10orf88 (Chromosome 10 Open Reading Frame 88) is a mitochondria-localized protein that is thought to be associated with protein-binding activity of mitochondria and plays a role in mitochondrial dysfunction and metabolic diseases. Studies suggest that C10orf88 may be involved in cellular metabolism, cell cycle regulation, and maintenance of mitochondrial homeostasis. Its activity is closely related to ATP synthesis and oxidative phosphorylation in mitochondria, and may be affected by a variety of metabolic regulators (e.g., metformin, AICAR) and cell cycle regulators (e.g., rosavitine). In addition, inhibitors of C10orf88 (e.g., oryzanamycin, rotenone) modulate its activity by affecting ATP synthase and electron transport chain complex I in mitochondria.