NRDE2 Polyclonal antibody

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NRDE2 Polyclonal Antibody for WB, IP, ELISA

Cat No. 24968-1-AP Copied!

Publications (5)

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Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, IP, CoIP, chIP, ELISA

Synonyms

C14orf102, Nuclear exosome regulator NRDE2, Protein NRDE2 homolog, UPF0614 protein C14orf102

• 

  WB analysis of MCF-7 using 24968-1-AP

  MCF-7 cells were subjected to SDS PAGE followed by western blot with 24968-1-AP (C14orf102 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  IP experiment of MCF-7 using 24968-1-AP

  IP result of anti-NRDE2 (IP:24968-1-AP, 5ug; Detection:24968-1-AP 1:500) with MCF-7 cells lysate 1200ug.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Tested Applications

• Positive WB detected in: MCF-7 cells
• Positive IP detected in: MCF-7 cells

Recommended dilution

• Western Blot (WB): WB : 1:500-1:1000
• Immunoprecipitation (IP): IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

24968-1-AP targets NRDE2 in WB, IHC, IP, CoIP, chIP, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Cited Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag21805

  Product name: Recombinant human C14orf102 protein

  Source: e coli.-derived, PET30a

  Tag: 6*His

  Domain: 615-933 aa of BC118673

  Sequence: AVHILTKLTESSPYGPYTGQVLAVHILKARKAYEHALQDCLGDSCVSNPAPTDSCSRLISLAKCFMLFQYLTIGIDAAVQIYEQVFAKLNSSVFPEGSGEGDSASSQSWTSVLEAITLMHTSLLRFHMKVSVYPLAPLREALSQALKLYPGNQVLWRSYVQIQNKSHSASKTRRFFDTITRSAKPLEPWLFAIEAEKLRKRLVETVQRLDGREIHATIPETGLMHRIQALFENAMRSDSGSQCPLLWRMYLNFLVSLGNKERSKGVFYKALQSCPWAKVLYLDAVEYFPDEMQEILDLMTEKELRVRLPLEELELLLED

• Full Name: chromosome 14 open reading frame 102
• Calculated Molecular Weight: 1164 aa, 133 kDa
• Observed Molecular Weight: 133 kDa
• GenBank Accession Number: BC118673
• Gene Symbol: NRDE2
• Gene ID (NCBI): 55051
• RRID: AB_2879825
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q9H7Z3
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Publications

What published studies show

The NRDE2 Polyclonal antibody (Cat# 24968-1-AP) has 5 total citations. These appear in Cell Genom, Genes & Development (×2), RNA Biology, and Journal of Virology. The research fields span DNA repair and hepatocellular carcinoma sensitivity to PARP inhibitors, nuclear RNA turnover and cytoplasmic transport regulation, exosome function, DNA damage accumulation prevention, and viral manipulation of host RNA quality control pathways.

Automatically generated from the 5 publication citations by Able AI.

• Human
• Mouse
• Rat
• Monkey
• Pig

Species	Application	Title
human	WB,IP,IHC	Cell Genom; NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors; Authors - Yahui Wang ; KD Validated
human	WB,IP,CoIP	Genes Dev; An Mtr4/ZFC3H1 complex facilitates turnover of unstable nuclear RNAs to prevent their cytoplasmic transport and global translational repression.; Authors - Koichi Ogami
human	WB,IP	Genes Dev; NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction.; Authors - Jianshu Wang ; KD Validated
human	WB,chIP	RNA Biol; NRDE-2, the human homolog of fission yeast Nrl1, prevents DNA damage accumulation in human cells.; Authors - Patricia Richard
human	WB	J Virol; Kaposi's Sarcoma-Associated Herpesvirus Fine-Tunes the Temporal Expression of Late Genes by Manipulating a Host RNA Quality Control Pathway.; Authors - Julio C Ruiz ; KD Validated