C1R Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 17346-1-AP

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Freight/Packing

Con: 46 μg/150 μl

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Species specificity:
human

Positive WB detected in:
human blood tissue

Positive IHC detected in:
human liver tissue

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
complement component 1, r subcomponent

Calculated molecular weight:
705aa,80 kDa

Observed molecular weight:
85 kDa, 30 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
C1R

Synonyms
C1R, Complement C1r subcomponent
Background

The first component of complement is a calcium-dependent complex of the 3 subcomponents C1q, C1r, and C1s. The serine protease subunits C1r and C1s form a Ca(2+)-dependent C1s-C1r-C1r-C1s tetramer. C1r acts by transforming the activation signal into an enzymic activity. C1r is a single-chain glycoprotein which can be cleaved into an A chain and a B chain upon activation. This antibody recognizes full-length C1r chain and the cleaved B chain.


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