Product Information
31200-1-PBS targets CCDC85C in applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag35157 Product name: Recombinant human CCDC85C protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 220-390 aa of NM_001144995 Sequence: HHHVPPPLLPPGPHKAPDGKAGATRRSLDDLSAPPHHRSIPNGLHDPSSTYIRQLESKVRLLEGDKLLAQQAGSGEFRTLRKGFSPYHSESQLASLPPSYQDSLQNGPACPAPELPSPPSAGYSPAGQKPEAVVHAMKVLEVHENLDRQLQDSCEEDLSEKEKAIVREMCN Predict reactive species |
| Full Name | coiled-coil domain containing 85C |
| Calculated Molecular Weight | 419 aa, 45 kDa |
| Observed Molecular Weight | 45-50 kDa |
| GenBank Accession Number | NM_001144995 |
| Gene Symbol | CCDC85C |
| Gene ID (NCBI) | 317762 |
| RRID | AB_3742406 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity Purification |
| UNIPROT ID | A6NKD9 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
Ccdc85c (coiled-coil domain containing 85c) is a gene encoding protein, which is located on human chromosome 14 (14q32.2) and belongs to the helical loop domain protein family. The protein is mainly expressed in the neuroepithelial cells of the lateral ventricle wall of the brain, especially at the top junction of radial glial cells. In addition, it is also expressed in a variety of monolayer epithelial cells, but not in stratified epithelial cells. CCDC85C is the pathogenic gene of hereditary hydrocephalus and subcortical endometriosis (often accompanied by cerebral hemorrhage). In CCDC85C gene knockout (KO) mice and rats, abnormal development of ventricular system was observed, resulting in hydrocephalus and cerebral hemorrhage (PMID: 37271245).
