Product Information
87796-1-PBS targets CCRL1 in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
Peptide Predict reactive species |
| Full Name | chemokine (C-C motif) receptor-like 1 |
| Calculated Molecular Weight | 350 aa, 40 kDa |
| Observed Molecular Weight | 40 kDa |
| GenBank Accession Number | BC069438 |
| Gene Symbol | CCRL1 |
| Gene ID (NCBI) | 51554 |
| RRID | AB_3745754 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | Q9NPB9 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
CCRL1/ACKR4 is an atypical chemokine receptor that functions primarily as a chemokine scavenger, binding CCL19, CCL21, CCL25, and CXCL13 to shape local chemokine gradients rather than inducing classical GPCR-mediated chemotaxis. Expressed in lymphatic endothelium, epithelial barriers, and stromal compartments, ACKR4 plays a key role in dendritic cell trafficking, lymphocyte positioning, and tissue immune homeostasis. Dysregulation of ACKR4 can alter barrier immunity, inflammatory responses, and tumor immune organization, highlighting its importance as a non-signaling regulator of chemokine networks.
