CCRL1 Recombinant monoclonal antibody

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• CCRL1 Recombinant monoclonal antibody (87796-1-RR)

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  WB analysis using 87796-1-RR

  Various lysates were subjected to SDS PAGE followed by western blot with 87796-1-RR (CCRL1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours.

CCRL1 Uni-rAb^® Recombinant Antibody for WB, ELISA

Cat No. 87796-1-RR

Clone No.253268H4

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Synonyms

ACKR4, Atypical chemokine receptor 4, C-C chemokine receptor type 11, CC chemokine receptor-like 1, C-C CKR-11

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Tested Applications

• Positive WB detected in: K-562 cells, HepG2 cells

Recommended dilution

• Western Blot (WB): WB : 1:2000-1:10000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

87796-1-RR targets CCRL1 in WB, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: chemokine (C-C motif) receptor-like 1
• Calculated Molecular Weight: 350 aa, 40 kDa
• Observed Molecular Weight: 40 kDa
• GenBank Accession Number: BC069438
• Gene Symbol: CCRL1
• Gene ID (NCBI): 51554
• RRID: AB_3745754
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q9NPB9
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

CCRL1/ACKR4 is an atypical chemokine receptor that functions primarily as a chemokine scavenger, binding CCL19, CCL21, CCL25, and CXCL13 to shape local chemokine gradients rather than inducing classical GPCR-mediated chemotaxis. Expressed in lymphatic endothelium, epithelial barriers, and stromal compartments, ACKR4 plays a key role in dendritic cell trafficking, lymphocyte positioning, and tissue immune homeostasis. Dysregulation of ACKR4 can alter barrier immunity, inflammatory responses, and tumor immune organization, highlighting its importance as a non-signaling regulator of chemokine networks.