|Positive IF detected in
|Positive FC detected in
|IF : 1:50-1:500
|This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
|Sample-dependent, check data in validation data gallery
65050-1-Ig targets CD107a / LAMP1 in IF, FC (Intra) applications and shows reactivity with Mouse samples.
|Host / Isotype
|Rat / IgG2a, kappa
|Plasma membrane fraction of mouse embryo NIH/3T3 cell line
|lysosomal-associated membrane protein 1
|GenBank accession number
|Gene ID (NCBI)
|PBS with 0.09% sodium azide.
|Store at 2-8°C. Stable for one year after shipment.
LAMP1 (CD107a) is a heavily glycosylated membrane protein enriched in the lysosomal membrane. LAMP1 is extensively glycosylated with asparagine-linked oligosaccharides which protect it from intracellular proteolysis (PMID: 10521503). Although LAMP1 is expressed largely in the endosome-lysosomal membrane of cells, it is also found on the plasma membrane (PMID: 16168398). Elevated LAMP1 expression at the cell surface has also been detected during platelet and granulocytic cell activation, as well as in some tumor cells (PMID: 29085473). LAMP1 functions to provide selectins with carbohydrate ligands. This protein has also been shown to be a marker of degranulation on lymphocytes such as CD8+ and NK cells and may also play a role in tumor cell differentiation and metastasis (PMID: 18835598; 29085473; 9426697).
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