FITC Anti-Mouse CD107a (1D4B)

CD107a Monoclonal Antibody for FC

Host / Isotype

Rat / IgG2a

Reactivity

Mouse

Applications

FC (Intra)

Conjugate

FITC Fluorescent Dye

CloneNo.

1D4B

Cat no : FITC-65050

Synonyms

AI196048, CD107a, Lamp 1, Lamp1



Tested Applications

Positive FC detected inNIH/3T3 cells

Recommended dilution

ApplicationDilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Product Information

FITC-65050 targets CD107a in FC (Intra) applications and shows reactivity with Mouse samples.

Tested Reactivity Mouse
Host / Isotype Rat / IgG2a
Class Monoclonal
Type Antibody
Immunogen Plasma membrane fraction of mouse embryo NIH/3T3 cell line
Full Name lysosomal-associated membrane protein 1
GenBank accession numberBC006785
Gene symbol Lamp1
Gene ID (NCBI) 16783
Conjugate FITC Fluorescent Dye
Excitation/Emission maxima wavelengths494 nm / 520 nm
Form Liquid
Purification Method Affinity purification
Storage Buffer PBS with 0.1% sodium azide.
Storage ConditionsStore at 2-8°C. Avoid exposure to light.

Background Information

LAMP1 (CD107a) is a heavily glycosylated membrane protein enriched in the lysosomal membrane. LAMP1 is extensively glycosylated with asparagine-linked oligosaccharides which protect it from intracellular proteolysis (PMID: 10521503). Although LAMP1 is expressed largely in the endosome-lysosomal membrane of cells, it is also found on the plasma membrane (PMID: 16168398). Elevated LAMP1 expression at the cell surface has also been detected during platelet and granulocytic cell activation, as well as in some tumor cells (PMID: 29085473). LAMP1 functions to provide selectins with carbohydrate ligands. This protein has also been shown to be a marker of degranulation on lymphocytes such as CD8+ and NK cells and may also play a role in tumor cell differentiation and metastasis (PMID: 18835598; 29085473; 9426697).

Protocols

Product Specific Protocols
FC protocol for FITC CD107a antibody FITC-65050Download protocol
Standard Protocols
Click here to view our Standard Protocols