|Positive FC detected in||human peripheral blood granulocytes|
|This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.|
|Sample-dependent, check data in validation data gallery|
65116-1-Ig targets CD11b in FC applications and shows reactivity with Human samples.
|Host / Isotype||Mouse / IgG1|
|Full Name||integrin, alpha M (complement component 3 receptor 3 subunit)|
|Calculated molecular weight||1152 aa, 127 kDa|
|GenBank accession number||BC096346|
|Gene ID (NCBI)||3684|
|Purification Method||Affinity purification|
|Storage Buffer||Phosphate based buffer with 0.09% sodium azide, pH 7.2.|
|Storage Conditions||Store at 2-8°C.|
Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11b, also known as Integrin alpha M or CR3A, belongs to the integrin alpha chain family. CD11b forms an α/β heterodimer with CD18 (integrin β2). CD11b/CD18 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PMID: 9558116; 20008295). CD11b/CD18 is a receptor for the complement protein fragment iC3b, and is also a receptor for fibrinogen, factor X and ICAM1 (PMID: 2971974; 15485828).