|Positive FC detected in
|This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
|Sample-dependent, check data in validation data gallery
65116-1-Ig targets CD11b in FC applications and shows reactivity with Human samples.
|Host / Isotype
|Mouse / IgG1, kappa
|Rheumatoid synovial cells and human monocytes
|integrin, alpha M (complement component 3 receptor 3 subunit)
|Calculated molecular weight
|1152 aa, 127 kDa
|GenBank accession number
|Gene ID (NCBI)
|PBS with 0.09% sodium azide.
|Store at 2-8°C. Stable for one year after shipment.
Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11b, also known as Integrin alpha M or CR3A, belongs to the integrin alpha chain family. CD11b forms an α/β heterodimer with CD18 (integrin β2). CD11b/CD18 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PMID: 9558116; 20008295). CD11b/CD18 is a receptor for the complement protein fragment iC3b, and is also a receptor for fibrinogen, factor X and ICAM1 (PMID: 2971974; 15485828).
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