|Positive FC detected in||mouse bone marrow cells, human PBMCs|
|This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.|
|Sample-dependent, check data in validation data gallery|
FITC-65055 targets CD11b in IF, FC applications and shows reactivity with Mouse, Human samples.
|Tested Reactivity||Mouse, Human|
|Host / Isotype||Rat / IgG2b, kappa|
|Immunogen||C57BL/10 mouse splenic T cells and concanavalin A-activated C57BL/10 splenocytes|
|Full Name||integrin alpha M|
|GenBank accession number||BC156991|
|Gene ID (NCBI)||16409|
|Conjugate||FITC Fluorescent Dye|
|Excitation/Emission maxima wavelengths||494 nm / 520 nm|
|Purification Method||Affinity purification|
|Storage Buffer||PBS with 0.09% sodium azide.|
|Storage Conditions||Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.|
Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11b, also known as Integrin alpha M or CR3A, belongs to the integrin alpha chain family. CD11b forms an α/β heterodimer with CD18 (integrin β2). CD11b/CD18 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PMID: 9558116; 20008295). CD11b/CD18 is a receptor for the complement protein fragment iC3b, and is also a receptor for fibrinogen, factor X and ICAM1 (PMID: 2971974; 15485828).
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