FITC Plus Anti-Mouse CD11b (M1/70)

CD11b Monoclonal Antibody for FC

Host / Isotype

Rat / IgG2b, kappa

Reactivity

Mouse, Human and More (1)

Applications

IF, FC

Conjugate

FITC Plus Fluorescent Dye

CloneNo.

M1/70

Cat no : FITC-65055

Synonyms

CD11b, CD11b/CD18, CR3, CR3A, F730045J24Rik, integrin alpha M, Itgam, Ly 40, Mac 1, Mac 1a, MAC1



Tested Applications

Positive FC detected inBalb/c mouse bone marrow cells, human PBMCs

Recommended dilution

ApplicationDilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

FITC-65055 targets CD11b in IF, FC applications and shows reactivity with Mouse, Human samples.

Tested Reactivity Mouse, Human
Cited Reactivitymouse
Host / Isotype Rat / IgG2b, kappa
Class Monoclonal
Type Antibody
Immunogen C57BL/10 mouse splenic T cells and concanavalin A-activated C57BL/10 splenocytes
Full Name integrin alpha M
GenBank Accession NumberBC156991
Gene Symbol Itgam
Gene ID (NCBI) 16409
RRIDAB_2883745
Conjugate FITC Plus Fluorescent Dye
Excitation/Emission Maxima Wavelengths495 nm / 524 nm
Form Liquid
Purification MethodAffinity purification
Storage Buffer PBS with 0.09% sodium azide.
Storage ConditionsStore at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Background Information

Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11b, also known as Integrin alpha M or CR3A, belongs to the integrin alpha chain family. CD11b forms an α/β heterodimer with CD18 (integrin β2). CD11b/CD18 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PMID: 9558116; 20008295). CD11b/CD18 is a receptor for the complement protein fragment iC3b, and is also a receptor for fibrinogen, factor X and ICAM1 (PMID: 2971974; 15485828).

Protocols

Product Specific Protocols
FC protocol for FITC Plus CD11b antibody FITC-65055Download protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle

Cell Chem Biol

Small-molecule MHC-II inducers promote immune detection and anti-cancer immunity via editing cancer metabolism

Authors - Ling Huang
mouseFC

Cell Commun Signal

Transfer of cGAMP from neuron to microglia activates microglial type I interferon responses after subarachnoid hemorrhage

Authors - Hanxiao Chang
mouseIF,FC

Int Immunopharmacol

Methionine enkephalin inhibited cervical carcinoma via apoptosis promotion and reduction of myeloid derived suppressor cell infiltrated in tumor.

Authors - Na Qu
mouseFC

Cell Death Dis

Lactate secreted by PKM2 upregulation promotes Galectin-9-mediated immunosuppression via inhibiting NF-κB pathway in HNSCC.

Authors - Hanyue Chang
mouseFC

Cell Death Discov

TRAF6 triggers Mycobacterium-infected host autophagy through Rab7 ubiquitination

Authors - Qinmei Ma
mouseFC

Bioact Mater

Targeted transplantation of engineered mitochondrial compound promotes functional recovery after spinal cord injury by enhancing macrophage phagocytosis

Authors - Jiaqi Xu