FITC Plus Anti-Mouse CD11b (M1/70)

CD11b Monoclonal Antibody for FC

Cat No. FITC-65055
Clone No.M1/70

Host / Isotype

Rat / IgG2b, kappa

Reactivity

human, mouse

Applications

IF, FC

M1/70, Ly 40, Itgam, integrin alpha M, CR3A

Formulation:  PBS and Azide
PBS and Azide
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

Please visit your regions distributor:


Tested Applications

Positive FC detected inmouse bone marrow cells, human PBMCs

Recommended dilution

ApplicationDilution
Flow Cytometry (FC)FC : 0.25 ug per 10^6 cells in a 100 µl suspension
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

FITC-65055 targets CD11b in IF, FC applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Cited Reactivityhuman, mouse
Host / Isotype Rat / IgG2b, kappa
Class Monoclonal
Type Antibody
Immunogen

fusion protein

Predict reactive species
Full Name integrin alpha M
Calculated Molecular Weight127 kDa
GenBank Accession NumberBC156991
Gene Symbol CD11b
Gene ID (NCBI) 16409
RRIDAB_2883745
Conjugate FITC Plus Fluorescent Dye
Excitation/Emission Maxima Wavelengths495 nm / 524 nm
FormLiquid
Purification MethodAffinity purification
UNIPROT IDE9Q604
Storage Buffer PBS with 0.09% sodium azide, pH 7.3.
Storage ConditionsStore at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Background Information

Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11b, also known as Integrin alpha M or CR3A, belongs to the integrin alpha chain family. CD11b forms an α/β heterodimer with CD18 (integrin β2). CD11b/CD18 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PMID: 9558116; 20008295). CD11b/CD18 is a receptor for the complement protein fragment iC3b, and is also a receptor for fibrinogen, factor X and ICAM1 (PMID: 2971974; 15485828).

Protocols

Product Specific Protocols
FC protocol for FITC Plus CD11b antibody FITC-65055Download protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle

Cell Chem Biol

Small-molecule MHC-II inducers promote immune detection and anti-cancer immunity via editing cancer metabolism

Authors - Ling Huang
mouseFC

Cell Commun Signal

Transfer of cGAMP from neuron to microglia activates microglial type I interferon responses after subarachnoid hemorrhage

Authors - Hanxiao Chang
mouseFC

Cell Death Discov

TRAF6 triggers Mycobacterium-infected host autophagy through Rab7 ubiquitination

Authors - Qinmei Ma

Neoplasia

Tumor microenvironment(TME) and single-source dual-energy CT(ssDECT) on assessment of inconformity between RECIST1.1 and pathological remission in neoadjuvant immunotherapy of NSCLC

Authors - Chao Sun
mouseIF,FC

Int Immunopharmacol

Methionine enkephalin inhibited cervical carcinoma via apoptosis promotion and reduction of myeloid derived suppressor cell infiltrated in tumor.

Authors - Na Qu
mouseFC

Cell Death Dis

Lactate secreted by PKM2 upregulation promotes Galectin-9-mediated immunosuppression via inhibiting NF-κB pathway in HNSCC.

Authors - Hanyue Chang
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