Anti-Human CD244 (2B4.69), PBS Only

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• Anti-Human CD244 (2B4.69), PBS Only (65270-1-PBS)

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  FC experiment of human PBMCs using 65270-1-Ig (same clone as 65270-1-PBS)

  1X10^6 human PBMCs were surface co-stained with CL750 Anti-Human CD56 and 0.2 ug Anti-Human CD244 (65270-1-Ig, Clone:2B4.69) and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L) at dilution 1:1000, or Mouse IgG1 Isotype Control. Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 65270-1-PBS in a different storage buffer formulation.

• 

  FC experiment of human PBMCs using 65270-1-Ig (same clone as 65270-1-PBS)

  1X10^6 human PBMCs were surface stained with 0.2 ug Anti-Human CD244 (65270-1-Ig, Clone:2B4.69) and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L) at dilution 1:1000, or Mouse IgG1 Isotype Control. Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 65270-1-PBS in a different storage buffer formulation.

CD244 Monoclonal Antibody for FC

Cat No. 65270-1-PBS

Clone No.2B4.69

Host / Isotype

Mouse / IgG1

Reactivity

human

Applications

FC

Synonyms

SLAMF4, 2B4, h2B4, NAIL, NK cell activation-inducing ligand

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65270-1-Ig

Product Information

65270-1-PBS targets CD244 in FC applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Mouse / IgG1
• Class: Monoclonal
• Type: Antibody
• Immunogen:

  N/A

• Full Name: CD244 molecule, natural killer cell receptor 2B4
• GenBank Accession Number: BC028073
• Gene Symbol: CD244
• Gene ID (NCBI): 51744
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein G purification
• UNIPROT ID: Q9BZW8
• Storage Buffer: PBS Only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

CD244, also known as SLAMF4 or 2B4, is a type I transmembrane glycoprotein belonging to the signaling lymphocyte activation molecule (SLAM) family. It consists of an extracellular segment with two immunoglobulin (Ig)-like domains, a transmembrane region, and a cytoplasmic domain containing tyrosine-based motifs (PMID: 9841922; 30546369). CD244 is present on natural killer (NK) cells, γδ T cells, a subset of CD8+ T cells, monocytes, basophils, dendritic cells, and myeloid-derived suppressor cells (MDSCs) (PMID: 30546369). It binds to CD48 with high affinity and transmits stimulatory or inhibitory signals that regulate immune function (PMID: 9841922; 18523281).