FcZero-rAb® Biotin Anti-Mouse CD41 (MWReg30) Rabbit Recombinant Antibody

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• FcZero-rAb® Biotin Anti-Mouse CD41 (MWReg30) Rabbit Recombinant Antibody (Biotin-FcA65674)

CD41 FcZero-rAb^® Recombinant Antibody for FC, ELISA

Cat No. Biotin-FcA65674 Copied!

Clone No. MWReg30

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Host / Isotype

Rabbit / IgG

Reactivity

mouse

Applications

FC, ELISA

Synonyms

Itga2b, GpIIb, integrin alpha 2b, MWReg30

• 

  FC experiment of mouse peripheral blood platelets using Biotin-FcA65674

  1x10^6 mouse peripheral blood platelets were surface stained with 0.25 ug Biotin Anti-Mouse CD41 (MWReg30) Rabbit RecAb (Biotin-FcA65674, Clone: MWReg30) (red) or FcZero-rAb® Biotin Rabbit IgG Isotype Control Recombinant Antibody (Biotin-FcA98136, Clone: 240953C9) (blue), and Streptavidin-CoraLite® Plus 647 Conjugate (CL647-PF00030). Cells were not fixed.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Tested Applications

• Positive FC detected in: mouse peripheral blood platelets

Recommended dilution

• Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in a 100 µl suspension

This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

Biotin-FcA65674 targets CD41 in FC, ELISA applications and shows reactivity with mouse samples.

• Tested Reactivity: mouse
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  N/A

• Full Name: integrin alpha 2b
• GenBank Accession Number: BC120493
• Gene Symbol: CD41
• Gene ID (NCBI): 16399
• RRID: AB_3746861
• Conjugate: Biotin
• Excitation/Emission Maxima Wavelengths: -
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q9QUM0
• Storage Buffer: PBS with 0.09% sodium azide, pH 7.3.
• Storage Conditions: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Background Information

The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID: 19118207). Integrin alpha-IIb (ITGA2B, CD41) is expressed on platelets, megakaryocytes and some hematopoietic progenitor cells (PMID: 11934866). This protein undergoes post-translational cleavage to yield disulfide linked light beta (25 kDa) and heavy alpha (125 kDa) chains, which join with integrin beta3 (CD61) to form a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. CD41/CD61 is crucial for platelet aggregation through binding of soluble fibrinogen.